Calendar

Dr. Sharmarke Mohamed

Dr. Sharmarke Mohamed

 

Bio

Dr. Sharmarke Mohamed Assistant Professor of Chemistry, Department of Applied Mathematics and Sciences

Address: P.O.Box: 127788, Abu Dhabi, UAE

Telephone: +971-(0)2-5018317

Fax: +971-(0)2-4472442

Email: 

CV

After obtaining his PhD at UCL in 2011, Dr. Mohamed served as a teacher of Chemistry and has also worked within the Particle Engineering Department of Sanofi’s generic drug development business, Zentiva. At Zentiva, Dr. Mohamed applied his knowledge of crystallization process development to improve the drug development process for a number of target candidates. His discoveries of novel drug solid forms led to the award of three patents. He has published widely in journals as varied as CrystEngComm, Crystal Growth & Design, International Journal of Pharmaceutics and Nature Reviews Drug Discovery.

Dr. Mohamed’s research interests lie at the intersection of X-ray Crystallography, Computational Chemistry and Materials Chemistry, with the overarching aim of bringing together experimentalists and theoreticians to better understand and predict the solid state structures and properties of organic molecules.

Dr. Mohamed also has a long-standing interest in chemical education and regularly partakes in chemical demonstrations and talks aimed at getting young people engaged in science. 

Education

  • PhD Chemistry, University College London, UK, 2011
  • MSci Chemistry, University College London, UK, 2007

Teaching Areas

  • Physical Chemistry
  • Solid State Chemistry
  • X-ray Crystallography

Research Interests

  • X-ray Crystallography
  • Computational Crystal Structure Prediction
  • Crystal Engineering

Publications

Google Scholar  Scopus

 

Journal Publications

  • Mohamed, S.* (2016). Solvent inclusion in the crystal structure of bis[(adamantan-1-yl) methanaminium chloride] 1,4-dioxane hemisolvate monohydrate explained using the computed crystal energy landscape. Acta Crystallographica Section E – Crystallographic Communications, 72(9), 1348-1352. DOI: https://doi.org/10.1107/S2056989016013256

     

  • Mohamed, S.*, Karothu, D. P. & Naumov, P. (2016). Using crystal structure prediction to rationalize the hydration propensities of substituted adamantane hydrochloride salts. Acta Crystallographica Section B - Structural Science Crystal Engineering and Materials, 72(4), 551-561. DOI: http://dx.doi.org/10.1107/S2052520616006326

     

  • Reilly, A. M.*, Cooper, R. I., Adjiman, C. S., Bhattacharya, S., Boese, A. D., Brandenburg, J. G., Bygrave, P. J., Bylsma, R., Campbell, J. E., Car, R., Case, D. H., Chadha, R., Cole, J. C., Cosburn, K., Cuppen, H. M., Curtis, F., Day, G. M., DiStasio Jr, R. A., Dzyabchenko, A., van Eijck, B. P., Elking, D. M., can den Ende, J. A., Facelli, J. C., Ferraro, M. B., Fusti-Molnar, L., Gatsiou, C.-A., Gee, T. S., de Gelder, R., Ghiringhelli, L. M., Goto, H., Grimme, S., Guo, R., Hofmann, D. W. M., Hoja, J., Hylton, R. K., Iuzzolino, L., Jankiewicz, W., de Jong, D. T., Kendrick, J., de Klerk, N. J. J., Ko, H.-Y., Kuleshova, L. N., Li, X., Lohani, S., Leusen, F. J. J., Lund, A. M., Lv, J., Ma, Y., Marom, N., Masunov, A. E., McCabe, P., McMahon, D. P., Meekes, H., Metz, M. P., Misquitta, A. J., Mohamed, S., Monserrat, B., Needs, R. J., Neumann, M. A., Nyman, J., Obata, S., Oberhofer, H., Oganov, A. R., Orendt, A. M., Pagola, G. I., Pantelides, C. C., Pickard, C. J., Podeszwa, R., Price, L. S., Price, S. L., Pulido, A., Read, M. G., Reuter, K., Schneider, E., Schober, C., Shields, G. P., Singh, P., Sugden, I. J., Szaleqicz, K., Taylor, C. R., Tkatchenko, A., Tuckerman, M. E., Vacarro, F., Vasileiadis, M., Vazquez-Mayagoitia, A., Vogt, L., Wang, Y., Watson, R. E., de Wijs, G. A., Yang, J., Zhu, Q., & Groom, C. R. (2016). Report on the sixth blind test of organic crystal structure prediction methods. Acta Crystallographica Section B - Structural Science Crystal Engineering and Materials, 72(4), 439-459. DOI: http://dx.doi.org/10.1107/S2052520616007447

     

  • Mohamed, S., & Syed, B. A.* (2013). Commercial prospects for genomic sequencing technologies. Nature Reviews Drug discovery, 12(5), 340-341. DOI: http://dx.doi.org/10.1038/nrd4006

     

  • Issa, N., Barnett, S. A., Mohamed, S., Braun, D. E., Copley, R. C. B., Tocher, D. A., & Price, S. L.* (2012). Screening for cocrystals of succinic acid and 4-aminobenzoic acid. CrystEngComm, 14(7), 2454-2464. DOI: http://dx.doi.org/10.1039/c2ce06325e

     

  • Bardwell, D. A.*, Adjiman, C. S., Arnautova, Y. A., Bartashevich, E., Boerrigter, S. X. M., Braun, D. E., Cruz-Cabeza, A. J., Day, G. M., Della Valle, R. G., Desiraju, G. R., van Eijck, B. P., Facelli, J. C., Ferraro, M. B., Grillo, D., Habgood, M., Hofmann, D. W. M., Hofmann, F., Jose, K. V. J., Karamertzanis, P. G., Kazantsev, A. V., Kendrick, J., Kuleshova, L. N., Leusen, F. J. J., Maleev, A. V., Misquitta, A. J., Mohamed, S., Needs, R. J., Neumann, M. A., Nikylov, D., Orendt, A. M., Pal, R., Pantelides, C. C., Pickard, C. J., Price, L. S., Price, S. L., Scheraga, H. A., van de Streek, J., Thakur, T. S., Tiwari, S., Venuti, E., & Zhitkov, I. K. (2011). Towards crystal structure prediction of complex organic compounds - a report on the fifth blind test. Acta Crystallographica Section B-Structural Science Crystal Engineering and Materials, 67, 535-551. DOI: http://dx.doi.org/10.1107/s0108768111042868

     

  • Mohamed, S., Tocher, D. A., & Price, S. L.* (2011). Computational prediction of salt and cocrystal structures - Does a proton position matter? International Journal of Pharmaceutics, 418(2), 187-198. DOI: http://dx.doi.org/10.1016/j.ijpharm.2011.03.063

     

  • Mohamed, S., Tocher, D. A.*, Vickers, M., Karamertzanis, P. G., & Price, S. L. (2009). Salt or Cocrystal? A New Series of Crystal Structures Formed from Simple Pyridines and Carboxylic Acids. Crystal Growth & Design, 9(6), 2881-2889. DOI: http://dx.doi.org/10.1021/cg9001994

     

  • Mohamed, S., Barnett, S. A., Tocher, D. A., Price, S. L.*, Shankland, K., & Leech, C. K. (2008). Discovery of three polymorphs of 7-fluoroisatin reveals challenges in using computational crystal structure prediction as a complement to experimental screening. CrystEngComm, 10(4), 399-404. DOI: http://dx.doi.org/10.1039/b714566g

     

  • Mohamed, S., Barnett, S. A., & Tocher, D. A. (2007). 7-Fluoroisatin-dimethyl sulfoxide (1/1). Acta Crystallographica Section E - Structure Reports Online, 63, O3575-U4120. DOI: http://dx.doi.org/10.1107/s160053680703526x

     

  • Shankland, K., Leech, C. K., Mohamed, S., Barnett, S. A., & Tocher, D. A. (2007). 7-Fluoroisatin - 1,4-dioxane (1/1). Acta Crystallographica Section E - Structure Reports Online, 63, O3574-U4110. DOI: http://dx.doi.org/10.1107/s1600536807035258

     

  • Mohamed, S., Barnett, S. A., & Tocher, D. A. (2007). 5-Fluoroisatin - dimethyl sulfoxide (1/1). Acta Crystallographica Section E - Structure Reports Online, 63, O3576-U4130. DOI: http://dx.doi.org/10.1107/s1600536807035271

     

  • Mohamed, S., Barnett, S. A., & Tocher, D. A. (2007). 5-fluoro-3-hydroxy-3-(nitromethyl)-1H-indol-2(3H)-one. Acta Crystallographica Section E - Structure Reports Online, 63, O3577-U4140. DOI: http://dx.doi.org/10.1107/s1600536807035283

  • Patents

    • Mohamed, S., Hejtmankova, L., Ridvan, L., Tkadlecova, M., & Dammer, O. (2014). Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl) cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol. World Intellectual Property Organization (WIPO) Patent No. WO 2014/000719 A1.

       

    • Vlasakova, R., Hajicek, J., Ridvan, L., Mohamed, S., & Verner, J. (2013). A new solid form of tapentadol and a method of its preparation. World Intellectual Property Organization (WIPO) Patent No. WO 2013/120466 A1.

       

    • Mohamed, S., Ridvan, L., Radl, S., Cerny, J., Dammer, O., Krejcik, L., & Stach, J. A. N. (2013). Method of preparing potassium salt of azilsartan medoxomil of high purity. World Intellectual Property Organization (WIPO) Patent No. WO 2013/156005 A1

       

      [/tab-page]

      XX